Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer: A Prospective Analysis of the EPIC Study

Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, case flavonoids, it has been suggested that their may increase PCa risk. We investigated associations between total and individual classes subclasses (poly)phenols PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer Nutrition (EPIC) cohort included 131,425 adult men from seven countries. (Poly)phenol at baseline was assessed by combining validated center/country-specific dietary questionnaires Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HR) 95% confidence intervals (CI). In total, 6939 incident cases (including 3501 low-grade 710 high-grade, 2446 localized 1268 advanced, 914 fatal Pca cases) identified during a mean follow-up 14 years. No observed either overall (HRlog2 = 0.99, CI 0.94–1.04) or according subtype. Null also found all (phenolic acids, lignans, stilbenes) results current large prospective study do not support any association incidence.